Estradiol Gel
Estrabet Estradiol 0.06% Gel Tablets available in Australia, USA, UK, Philippines, New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, Sydney, Melbourne, Brisbane, Perth, Adelaide, Canberra, London, Birmingham, Manchester, Liverpool, Leeds, Glasgow, Edinburgh, Quezon City, Manila, Davao City , San Jose, Sydney, Melbourne, Brisbane for hospitals, distributors, and export buyers. GMP-certified supplied across world with global shipping.
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Product Introduction
SALT COMPOSITION: Estradiol 0.06% w/w
Dosage Form: Gel (For Topical Use Only)
Storage: Store below 30Β°C. Protect from heat and direct sunlight. Keep out of reach of children.
Estrabet Gel 0.06% contains estradiol (17Ξ²-estradiol), a bioidentical estrogen identical to the primary female hormone produced by the ovaries. The transdermal gel formulation allows estradiol to be absorbed through the skin directly into systemic circulation, providing consistent estrogen levels while avoiding first-pass hepatic metabolism.
Estrabet Gel 0.06% is prescribed for estrogen replacement therapy (ERT) in women with estrogen deficiency, particularly during menopause and in other hypoestrogenic states. Treatment should be individualized and initiated under the supervision of a qualified healthcare professional.
Indications / Uses
Estrabet Gel 0.06% is indicated for:
Management of moderate to severe menopausal symptoms, including:
Hot flashes
Night sweats
Treatment of vulvar and vaginal atrophy due to estrogen deficiency
Estrogen replacement therapy in postmenopausal women
Prevention of postmenopausal osteoporosis when alternative therapies are unsuitable
Hypoestrogenism due to ovarian failure or surgical removal of ovaries
Secondary amenorrhea caused by estrogen deficiency
Supportive hormonal therapy as determined by the physician
Benefits
Effective relief of menopausal symptoms: Reduces vasomotor symptoms such as hot flashes and night sweats
Consistent hormone delivery: Maintains stable estradiol levels through transdermal absorption
Reduced hepatic impact: Avoids first-pass liver metabolism associated with oral estrogen
Supports bone health: Helps slow postmenopausal bone loss
Bioidentical estrogen: Mimics the bodyβs natural estrogen
Easy topical application: Non-invasive and convenient for daily use
Mechanism of Action
Estrabet Gel 0.06% restores estrogen levels by delivering estradiol transdermally into systemic circulation.
Mechanism of Action
Estrogen Receptor Activation:
Estradiol binds to estrogen receptors (ER-Ξ± and ER-Ξ²) in target tissues including the brain, bones, skin, and reproductive organs.
Hormonal Regulation:
Activation of estrogen receptors modulates gene expression involved in temperature regulation, tissue integrity, and reproductive function.
Symptom Control:
Normalization of estrogen levels reduces vasomotor symptoms and improves vaginal tissue health.
Bone Preservation:
Decreases bone resorption and helps maintain bone mineral density.
Side Effects
Common side effects:
Mild skin irritation, redness, or itching at the application site
Breast tenderness or swelling
Headache
Nausea
Bloating
Mood changes
Less common but serious side effects:
Increased risk of blood clots (DVT, pulmonary embolism)
Stroke or cardiovascular complications
Breast or endometrial changes
Gallbladder disease
Liver dysfunction
Visual disturbances or severe migraines
Seek immediate medical attention if you experience chest pain, sudden shortness of breath, severe headache, vision loss, or leg swelling.
Safety Advice
Alcohol:
Limit alcohol consumption, as excessive intake may increase estrogen-related risks.
Pregnancy & Breastfeeding:
Not recommended during pregnancy or breastfeeding.
Estradiol may cause harm to the unborn baby.
Effective non-hormonal contraception may be advised for women of reproductive potential.
Liver & Kidney:
Use with caution in patients with liver impairment.
Periodic liver function monitoring may be required.
Other Medical Conditions:
Inform your physician if you have a history of:
Blood clots or thromboembolic disorders
Stroke or cardiovascular disease
Breast cancer or estrogen-dependent tumors
Unexplained vaginal bleeding
Migraine headaches
Gallbla